Picasso
Picasso is a Graphics toolkit and application framework developed at the University of California, Berkeley in the very early 90s. It is primarily based on CLOS and runs on top of X11 with CLX (earlier versions used their own X10 FFI bindings, called XCL, and CLOS wrappers for X entities, called XCLOS; these don't seem to be available anymore). Relationships among object slots are managed by a lazy-evaluation one-way constraint? system, much like in Garnet. It also comes with a persistent CLOS interface to the POSTGRES relational database system (which is the basis for PostgreSQL) called SOH (found in src/widgets/soh in the 2.0 distribution).
Picasso is currently available from Berkeley's Sequoia 2000 project ftp server here.
Picasso is non-free (it prohibits commercial distribution).
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